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The normal cell speaks of suffering: Afternoon.
When you study cancer you begin to ask the question, what does the normal cell do?
MitoTracker staining does not alter the normal cell growth rate (with doubling time in the range of 1.2 ± 0.3 days).
Furthermore, most of the tested compounds showed weak cytotoxic effect against the normal cell lines L929.
However, the selective cytotoxicities toward MCF-7 were found among these derivatives, together with no toxicity in the normal cell.
Furthermore, 11b exhibited much better selectivity toward the normal cell lines L929 and Vero than etoposide, 5-Fu and podophyllotoxin.
All of the synthesized target compounds 1 3 demonstrated potent cytotoxic activity against the cancer cell lines, but weak inhibitory activity toward the normal cell line.
The biological importance of the compound is that it has almost no effect (less than 26.7%) on the normal cell line, Vero cell line.
In contrast, in the normal cell line (L929), cell viability was decreased only by free or liposomal PTX in the highest concentrations.
The result indicated that MTX-CS NGs could reduce side effect on the normal cell.
In vitro cytotoxicity of Sgc8-FSNPs was evaluated in the normal cell lines 293T and L-02.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com