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The cost of the necessary remodelling and renovations is expected to exceed €19 million.
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They also noted that it was ready for the necessary remodeling, an important factor in a business that is developing so rapidly that the time it would take to build a new facility could cost a company an important slice of market share.
The shorter helical repeat distance within poly dA.dT tracts, along with a narrower and deeper minor grove with a defined spine of hydration, appear to energetically disfavour the necessary remodeling of these tracts for nucleosome binding (for review see [ 7]).
Our results indicate that early stages of β-cell mass expansion are associated with activation of an inflammatory immune response that could facilitate the necessary remodeling while preventing activation of an apoptotic cascade.
Little is known about the necessary outward remodeling of VSMC, although this is highly important [ 17].
Deficiencies in NER factors impede the recruitment of other necessary remodeling factors that modify chromatin.
"We have been offering to put money in to make necessary remodels -- the building needs a lot of work -- and we're trying to negotiate but they have been very nonresponsive". .
A second, related question is whether such overexpression might provide the necessary replication-independent chromatin remodeling, thereby reducing the requirement for c-Myc as a catalyst.
We further propose that in vivo, non-cancerous cells located within the tumor micro-environment may be capable of providing the necessary mechanical stimulus during the remodeling of the extracellular matrix surrounding the tumor.
Indeed they could contribute to the remodelling mechanisms enabling the necessary expansion of the pancreatic β-cell by controlling apoptosis in a PPARγ dependent pathway.
The fund nixed Denny Chief Nelson Marchioli's ambitious remodeling plans because the necessary financing could only come by diluting its stock.
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