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Parsing a total of 341 informative sites, we found a preponderance (315 to 26) of C to T (or G to A) mutations over the reverse suggesting that the mutation path from C to T remains the most common scenario in the case of LTR retrotransposon-related sequences.
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With such empirical relationship between the two basic nucleotide differences, we propose a probable mutation path to explaining the relationships.
Studies of particular mutation paths revealed that long disorder might just appear to vanish suddenly (Fig. 3E).
Eqn (1) allows us to calculate a fitness value for each node in any of the 120 mutational paths, provided that the mutation effects on the properties are known.
For both families, we chose ten random paths from the youngest individuals to the common ancestor and forced the mutation to be passed through generations in these paths.
The peak residues clearly form a path between the ligand and the mutation residues.
Nevertheless, they contain very valuable information, as cells that share a common developmental path tend to share the mutations that occurred along this path.
Given a founder, all family members in the path from the founder to proband must have the mutation as well.
Estimating the mutation rate in RNA viruses and retroviruses is critical but also challenging for tracing their rapidly evolving paths.
How did the mutation begin?
(a) The mutation matrix.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com