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The mutation is present in about 1 in 30 African Americans in this country; about 7percentt of the people with the mutation will develop the disease.
This gene was previously reported to cause a very rare and severe type of epilepsy when the mutation is present in all or most of the cells of the body.
(This mutation is usually seen in gliomas that strike adults under the age of 45). The researchers have devised a way to rapidly check for the mutation during brain surgery, and if the mutation is present, they can implant microparticles that gradually release the drug over several days or weeks.
The time during which virus is sensitive to 2F5 mAb-mediated neutralization is approximately 3-fold longer when the mutation is present.
We were unable to detect any dhfr 164L mutants in 158 samples collected in this study using a modified version of the same method, suggesting that if the mutation is present in this region, it remains extremely rare (Ochong E et al, in preparation).
When the mutation is present, a 370-bp band appears.
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The fraction of the reads containing the mutation is presented in Additional file 3: Table S1.
In women, however, the mutation was present in roughly the same fraction in both age groups.
Appropriate ddNTP was used to block the extension when the mutation was present, while the other three dNTPs enabled elongation of the primer.
Norwegian epidemiologists first called attention to the problem last week when they reported that the mutation was present in 12 of 16, or 75percentt, of viruses isolated in that country from patients in the earliest part of the influenza season, in November and December.
When 4 or more clonal HIV-1 variants from a single time point were available for analysis, a reversion or forward mutations was counted when the mutation was present in 50% or more of the clonal HIV-1 variants.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com