While heparin has historically received most of the scientific attention for its anticoagulant activity, interest has steadily grown in the multi-faceted role heparan sulfate plays in normal and pathophysiology.
Recently, a number of studies have elucidated the multi-faceted role of MTDH in tumor progression.
The multi-faceted role of the SWI/SNF complex provides a tantalising hint to the potential utility of targeted approaches in signalling pathways that are transcriptionally dysregulated by loss of SWI/SNF function (Wilson and Roberts, 2011).
However, further investigation to understand the cumulative influence that gene interactions have and the multi-faceted role that PPAR and other core biological pathways have on phenotypic expression of growth and carcass traits is warranted.
At the same time, the nature of bidirectional signaling of the Eph/ephrin system, and contribution of cell-type and context-dependent factors to the multi-faceted role of Eph receptors in cancer cells may complicate the development of effective therapeutic agents.
While the multi-faceted role of CPs has been revealed, the mechanisms regulating their trafficking in the cell, including specific receptors that determine the committed pathways by which individual CP is sorted to a specific compartment (e.g. lysosomes, plasma membrane, multivesicular bodies and extracellular milieu) remain largely unknown.
At this level, the system is viewed from a human-centric perspective and reflects the complexity of defining the multi-faceted role of the human in relation to the other elements of the system such as tasks, tools and technologies, physical environment and organisational issues (Smith and Sainfort 1989).
In this review, we summarize the recent findings to illustrate the multi-faceted roles of Cdk5 in synaptic plasticity through affecting dendritic spine formation, ion channel conductance, protein expression, and transcription in the postsynaptic neurons.
There are seven CanMEDS roles, each outlining key physician competencies to address the multi-faceted roles that physicians play.
Due to the multi-faceted roles for autophagy in maintaining cellular and organismal homeostasis and responding to diverse stresses, malfunction of autophagy contributes to both chronic and acute pathologies.
Given the multi-faceted roles of zinc in biology and the alarmingly high deficiency rate observed in human populations, the importance of research into zinc is starting to be appreciated.
