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"I think this is the most significant issue," he said.
Nothing's getting done on the most significant issue facing them".
The most significant issue is the Florida "Stand Your Ground" law.
The most significant issue to be resolved was how the electors themselves would be chosen.
That relationship is probably the most significant issue at stake in these elections.
The most significant issue is the relation between hearing loss and dementia.
Similar(5)
Despite the announcements on Tuesday, however, the young agency has yet to confront many of the most significant issues.
Today, debris is one of the most significant issues keeping Haitians from rebuilding Port-au-Prince and resuming normal lives.
In a statement, Waste Management's chief executive, A. Maurice Myers, called the settlement fair, saying it would "put to rest the most significant issues from the past".
The one that concerns me most of all of these, Mr. Chairman, is the selection of federal judges, who will serve for decades and will often have the last word on some of the most significant issues our society faces.
But you don't tell us where he stands on one of the most significant issues of our time — world poverty, and America's lamentably stingy and often misdirected foreign aid program.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com