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"the most significant difference" is grammatically correct and commonly used in written English.
It refers to the most important or noticeable difference between two or more things or concepts. You can use it whenever you want to emphasize that a particular difference stands out among others. Example: "The most significant difference between the two companies is their approach to customer service."
Exact(57)
Both transgressors escaped punishment, but the most significant difference between the incidents was in their outcome.
I believe it will be the most significant difference we can make in support for litigants".
It is no surprise that Rivera, the most significant difference between the two evenly matched teams, was the most significant difference in the most important moments of the series and was named the series' most valuable player.
–What do you think is the most significant difference between the athletic ability of males and females?
But the most significant difference might be in the penalty-shot competition that decides tie games in the medal round.
The most significant difference is in the pronunciation of c before i or e.
That may well be the most significant difference between the Clinton-Giuliani race that almost was and that Clinton-Giuliani race that could now be about to unfold.
But perhaps the most significant difference was that, in Britain, the authorities decided to let the nation judge the child killers.
The most significant difference between a Muve and other distance training platforms is the opportunity it gives to incorporate non-verbal forms of communication.
The most significant difference in the recipes I dig up is the raising agent responsible for the madeleine's characteristic fluffy texture.
The most significant difference shows up in Eakin's superior Tennessee Comprehensive Assessment Program (TCAPs) annual achievement test scores; Eakin outscores Glenview in all areas.
More suggestions(15)
the most significant deed
the most significant change
the most significant part
the most significant litigation
the most significant figure
the most significant advance
the most enormous difference
the most common difference
the most significant addition
the most striking difference
the most significant point
the most significant discovery
the most radical difference
the most significant support
the most important difference
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com