The most frequent treatment protocol is currently to administer 7.4 GBq for up to four times with a 6 to 10-week interval between each administration [19].
Furthermore, the DAP for cabazitaxel indicated that the most frequent and most severe protocol violations for the phase 3 registration study were for missing pain assessments or analgesic scores, with less than 50% of each treatment group reporting analyzable data.
Among the protocol's recommended treatments, the most frequent was the European Berlin-Frankfurt-Munster (BFM-90) group protocol, adopted by the Brazilian National Cancer Institute, which recommends short, intensive multidrug leukemia therapy.
The need to standardize management and to follow protocols was the most frequent recommendation in the discussions of cases by the committees.
There were no notable differences between the treatment arms in the number of patients excluded from the per protocol population, the most frequent reasons for exclusion were lost to follow-up before or at day 63 and PCR missing or indeterminate before or at day 63 (DHA/PQP: 35 patients: AS+MQ: 19 patients).
The most frequent contributory factors were inefficient or poorly followed protocols by staff (n = 308, 52%); lack of, or insufficient, organisational protocols (n = 184, 31%); and environmental issues such as a lack of equipment availability (n = 97, 16%).
None of the 27 samples displayed gain at 5p, the most frequent genetic alteration previously reported in a series of CxSCC analysed using an identical protocol.
Table 1 lists the most frequent abnormal patterns of cDNA termini detected in the 172,229 UGALAB ESTs generated using the exact protocol shown in Figure 1.
The multiscale modeling protocol was developed for temozolomide (TMZ), the cornerstone of chemotherapy against glioblastoma multiforme (GBM), the most frequent primary brain tumor in adults.
Cars were the most frequent culprits.
It's also the most frequent churchgoers.
