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Over the past two centuries this has most often happened during the most extreme instance of national purpose: mass warfare.
The inverse mechanic of Time's Arrow is maybe only the most extreme instance in his work of cause and effect being shot.
In perhaps the most extreme instance, Kohlberg Kravis Roberts sold Primedia for $525 million, closing out a 22-year investment in the media company.
(The most extreme instance of such an approach is undoubtedly the hold-up in L'Argent, which we don't see at all - it's thanks to the soundtrack alone that we know what's going on).
N.H.L. general managers have scrambled to fill the gaps, with the most extreme instance coming Dec. 12, when the Capitals asked their Web site producer to dress as a backup.
This was not only a deeply un-Christian and unkind phrase for a Christian pastoral leader to use, it was, as it turned out, the most extreme instance of clerical hypocrisy I have ever encountered.
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Eureka's sales director, Ian Sadler, tells me he volunteered to trim the most extreme instances of the sexual sadism that was supposed to be at issue.
In the most extreme instances children are used on the frontlines of battle and may be forced to commit terrible atrocities against their own families, friends and communities.
Investigators with the Houston Police Department were still piecing together what life was like inside the room for the men, but officials said the case was one of the most extreme instances of elder abuse and financial exploitation in Texas.
In the most extreme instances, the report predicted, doubts about the ability or commitment of the United States to remain the region's dominant military power could one day grow strong enough to drive Japan to more drastic measures, like either embracing China or building its own independent deterrent, including nuclear weapons.
By focusing on low-coverage long reads and short reads with high coverage, we wished to stress-test all assemblers against the most extreme instances of the sequence assembly problem, especially, where assembly quality is of essence.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com