Of all the classes considered, prostaglandin inhibitors had the highest probability of being the most effective class for delaying preterm delivery and had the most favorable maternal side effect profile.
Proton pump inhibitors are the most effective class of agents employed in the treatment of GERD.
Among the multiple cell types assessed as therapeutic treatment for neural insults, stem cells have emerged as possibly the most effective class.
Treatment effects were in the medium to large range, with a number needed to treat (NNT) of only 3, comparable to the most effective class of medications (antipsychotics).
Bisphosphonates (BPs) are the most effective class of anti-resorptive drugs currently available and are frequently used in the clinical treatment of OP, owing to the great advantages.
In cases of mild to moderate hyperglycemia (eg, A1c <9%), insulin monotherapy may not provide any benefit over other diabetes agents, but nonetheless remains the most effective class of agents to control hyperglycemia.
Presently, PPIs are the most effective class of drugs for relieving GERD-related symptoms, as well as healing and maintaining remission of erosive esophagitis, and improving health-related QOL.
Although bisphosphonates (BPs) are the most effective class of anti-bone-resorptive drugs currently available and the most commonly prescribed for the clinical treatment of OP, they are known to cause serious side effects such as bisphosphonate-related osteonecrosis of the jaw.
As the extent of inhibition depends on the nature of inhibition (competitive, uncompetitive, mixed), the current technology can also be exploited to choose the most effective class of inhibitors and, to a certain extent, reduce the chances of failure in translating nanomolar enzyme potencies into MICs.
The current AST-ASTS practice guidelines recommend lipid-lowering therapy for all kidney transplant recipients with fasting triglyceride levels ≥ 5.65 mmol/L, LDL cholesterol ≥ 2.59 mmol/L, or non-HDL-cholesterol ≥ 3.36 mmol/L, regardless of cardiovascular status, and notes that statins are the most effective class of antilipemic drugs for lowering LDL.
