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Instead of the most common trial and error technique for the ANN's training, DOE was found to be a better methodology.
The work concludes that the design of experiments (DOE) methodology constitutes a better approach to the design of RBF networks for roughness prediction than the most common trial and error approach.
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The most common pre-trial OAD other than metformin was a SU.
The most common spontaneous breathing trial method was T-tube, and the median time from intubation to spontaneous breathing trial was similar between groups (5.7 days in the Control group and 5.5 days in the Rest group; p = 0.2).
The most common barriers to trial publication included economic or personal interests, lack of sufficient funding for a comprehensive trial registry, differing legal regulations, and concerns over patient privacy.
The most common reasons for trial participation were to contribute to medical science and to have improved treatment outcomes.
Among survey respondents (50% response rate), the most common reason for trial registration was a publication requirement and for non-registration, a lack of familiarity with the process.
During the second year, the most common reason for trial withdrawal was 'other' (e.g. participants who withdrew consent, were lost to follow-up, or moved) in the liraglutide groups and 'ineffective therapy' in the glimepiride group (figure 1).
Of 865 co-enrollments involving 713 patients, the most common other international trials tested pharmaconutrition, intensive glucose control, sedation interruption and high frequency oscillation (Table 1).
Insufficient accrual was the most common reason provided for trial closure (n = 23, 25.3%).
Physician recommendation was the most common reason cited for trial participation.
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