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The most common grade 3 adverse events in the combination arm included neutropenia, leukopenia, anemia and neutropenic fever.
The most common grade 3 or higher toxicity was neutropenia (45.9%), and thrombocytopenia was observed in 13.5% of patients.
The most common grade 3 and 4 nonhematologic adverse events were neutropenic fever (25%), nausea (18.8%), and mucositis (9.4%).
The most common grade 3 4 events were haematological.
The most common grade 3 or 4 toxicity was neutropenia.
The most common grade 3 late toxicity was laryngeal stricture.
The most common grade 3/4 toxicities were hematological toxicities.
The most common Grade ≥ 3 toxicities were fatigue and diarrhoea.
The most common grade 3 4 toxicity was neutropenia (57%).
The most common grade ≥3 AEs were haematological (45%), fatigue (10%), and pneumonia (7%).
In 153 treatment cycles delivered, the most common grade 3/4 event was lymphopoenia.
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