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Yet as the modified mice entered adulthood, they were less capable of weakening connections that already existed, and that made it hard for them to form robust new long-term memories.
At first glance, the modified mice had apparently normal eyes: The lens cells had lost their nuclei and other internal structures.
Each night, according to sensors on the wheels in the mice's cages, the modified mice ran six times farther than normal mice.
Compared to normal mice, the modified mice had very low levels of cholesterol both in the blood and the liver; they also had about 20% to 60% less total sterols.
When the maze was set up where the mice could only use one of the cues (visual or sensory), the modified mice were no faster than the control mice.
When the maze was set up with visual and sensory cues hinting at where the food was, the modified mice learned to navigate the maze in around eight days compared to 12 days for the control mice, New Scientist reported.
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The scientists who created the modified mouse stripped away a gene known as Hgmic, which appears to play a role in helping mice store fat.
Experimental tumors were generated by transplantation of the modified mouse mammary carcinoma cells into immunocompetent mice.
This means the virus can infect the cells of these modified mice.
The performance of the genetically modified mice improved once the researchers turned on their PrPc-making genes.
In the floating test, normal mice spent about 50% more time drifting than did the genetically modified mice, the researchers report online today in Immunity, suggesting the animals are more vulnerable to depression if they carry the receptor.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com