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Incorporating the modifications into the third oligonucleotide strands has little effect on the structure of the triplexes.
Those difficulties motivate the study reported herein, in which a general strategy to improve the standard condensation methods by taking into account a priori information of the modifications into the viscoelastic zones is introduced.
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Always willing to experiment and adjust on the fly, Buehler found something he liked and carried the modification into the game.
More often, however, PTMs affect the interactions between their targets and other cellular factors that function as effectors by translating the modification into a biological action (Fig. 1).
Our results suggest that the combination of S10 phosphorylation with K9 methylation can reverse this effect and turn the modification into a silencing mark.
Coons et al. [ 7] categorised the magnitude of the modification into three levels, whereby the potential effect on the content, meaning, or interpretation of the measure's items and/or scales is assessed.
135 prohibits the selection of the gender of the progeny, unless gender related hereditary diseases have to be prevented and moreover "any intervention aimed at modifying the human genome may be undertaken only for preventive or therapeutic purposes and not for the purposes of introducing the modification into the genome of the progeny".
The EGS library (Fig. 4B), which contains a randomized anti-sense domain of the "3/4 EGS", was generated by introducing the following modifications into the framework: the anti-sense domain was composed of random bases; The "CCA" sequence[ 7, 8, 28, 47, 48] located in the 3'-terminus is important for the EGS effect.
Introduction of these modifications into the quantum-mechanical formulation of the crystal field theory improves the agreement of its quantitative predictions with experimental observations.
Specific retrieval procedures have been developed to take into account the modifications in the line geometry.
For the modifications in 1916 1917, Kolberg went into drydock at the Kaiserliche Werft in Kiel.
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