Sentence examples for the modification of target from inspiring English sources

Being mobile, impurity atoms, vacancies and interstitials can recombine and/or precipitate in the form of stable complexes which leads to the modification of target material properties.

The modification of target specificity not only changes the local microcircuit at the level of specific cell types but also the overall level of excitation in the network.

Such modification is accomplished by complementary base pairing between specific regions of the snoRNA and target RNA by the small nucleolar ribonucleoprotein complex which guides the modification of target RNA.

In the aftermath of his failed reform, Kosygin spent the rest of his life improving the economic administration through the modification of targets; he implemented various programmes to improve food security and ensure the future intensification of production.

Various errors in DSB processing create signals (e.g., Rad51-coated single-stranded DNA), and through checkpoint pathways, these signals lead to the modification of targets with the result of controlling cell-cycle progression, DNA repair, programmed cell death, and in some cases development (reviewed by Hochwagen and Amon 2006).

If a mutation is not introduced, the target site is again targeted by CRISPR/Cas9, and once mutations are introduced the region is no longer targeted because of the modification of the target DNA sequence.

Numerous methods have been developed to address these issues, from the screening of various expression systems to the modification of the target protein itself.

For example, pharmacological activation of AMPK inhibits protein synthesis via the modification of mammalian target of rapamycin (mTOR) pathways.

Conversely, DNA binding can induce the modification of a target protein.

Therefore, the interaction of HESX1 with DNMT1 suggests that HESX1 might exert part of its repressing activity through the modification of the target gene expression patterns.

By combining known information with new predictions, a possible new model emerges which links past clinical and experimental observations of Wilms' tumor to the misregulation or loss of WT1 and/or the modification of its target genes.