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Prior to monoculturing HSC-3 tongue cancer cells, the model underwent modifications in oxygenation level (1%O2 hypoxia to upregulate CAV1) and/or in the amount of natural soluble factors [deleted by 14-day rinsing (rinsed myoma, RM), to allow only HSC-3-derived factors to act].
29 Throughout its development the model underwent a thorough process of repeated testing against the data, to examine and challenge its capacity to represent all participant experiences.
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While the model undergoes further testing and evaluation, the memo said its implementation is "paused" with no new target date.
As either of these two parameters is increased, the model undergoes a transition from periodic to chaotic behavior according to the universal quasi-periodicity route to chaos.
The model undergoes the usual phenomenon of backward bifurcation exhibited by similar vector-borne disease transmission models.
The model undergoes competitive exclusion (where Strain i drives out Strain j to extinction whenever R0i>1>R0j;i,j= 1,2,i≠j).
Furthermore, the model undergoes competitive exclusion, where the strain with the higher reproduction number (greater than unity) drives the other (with reproduction number less than unity) to extinction.
From a global perspective, it is also shown that the model undergoes strong resonances, such as the resonance 1 4, by using a continuation procedure.
The model undergoes a backward bifurcation, where a stable disease-free equilibrium co-exists with a stable endemic equilibrium when the associated reproduction threshold is less than unity.
Numerical simulations of the model suggest that the model undergoes the phenomenon of competitive exclusion, where the strain with the higher reproduction number (greater than unity) drives the other to extinction.
A parametric study is carried out, that varies each of the model material parameters, and observes their effect on design-relevant response characteristics of the model undergoing a thermomechanical cycle.
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