Exact(60)
The model estimation scheme also provides interval estimates of the smooth terms which does not incur any additional simulations.
Between and within patient variability was estimated as part of the model estimation procedure in NONMEM.
One advantage of MI is that the standard errors and CIs of the estimates are directly available as part of the model estimation.
In particular, it is known that as the HDC model estimates are not unique, it is necessary to impose some constraints on the model estimation process.
The state estimate system is the same as the conventional KF, but the model estimation system continuously updates the model parameters.
The mean (median) of the model estimation parameters indicates that the long-term unconditional expectation decreases from the OLS estimates 0.056226 (0.041286) to 0.047367 (0.047367).
Table 1 shows the results of the model estimation.
The model estimation is made in three successive steps.
This will directly affect the validity of the model estimation.
Thus, the data set was reasonably sufficient for the model estimation.
This is required in order for the model estimation results to be interpretable.
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