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Having a non-adjacent pair of proteins in PPINs does not mean they cannot interact at all, and we cannot label the missing interaction as a TN.
Despite the missing interaction between the factors Emotion and Group, we carried out these analyses: results confirm that both groups show a (marginally) significant Emotion effect (controls: (F 4, 44) = 2.43, p = .07); patients: (F 4,44) = 9.50, p<.0001).
Therefore, L-GRAAL's alignment of yeast edge (MRPS5, MRP17) predicted the missing interaction in human data from BioGRID.
The second step uses the origin destination interaction patterns of the harmonised migration flows and covariate information to estimate the missing interaction patterns.
This is in line with the missing interaction of the factors safety on the treadmill and session in Experiment 2. Participants in Experiment 2 obviously felt very confident on the treadmill, which might explain why cortisol levels did not increase.
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In these cases, ExSpeU1s probably compensate the missing interactions and facilitate the formation of the correct network of splicing factors over the exon.
Between many pairs of groups, the missing interactions can be perfectly imputed (relative rank of 0), whereas between others, the task seems incredibly difficult (e.g. between groups 4 and 24 the average relative rank of the left-out edge was 0.63).
Another contributory cause for the missed interaction can be that only DSP's and PDSN's are involved in the care of the family and the discharge process during the hospital stay.
Some of the missed interactions may be false positives, and thus at this front our analysis would serve to purge such data from the genetic interaction maps.
There is also a missing interaction between RAC1 and " Regulation of actin cytoskeleton".
The abundance of missing interactions makes the normalization of the interaction overlap impractical.
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