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Better characterization of CNVs in order to determine the minimal affected region and which genes or DNA regions within them are likely to be key in contributing to the phenotype.
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Although the size of the duplication varies among different patients and includes several genes, the minimal critical region in all of the affected cases includes MECP2.
We found no correlation (Additional file 2: Figure S2), and therefore concluded that any change induced by the assay itself was minimal and affected all samples to an equal extent.
Do the minimal research.
Why the minimal reaction?
The minimal fridge.
(The minimal feature).
The minimal finance charge.
Also, in the early stages of AMD the affected areas are minimal with respect to the tissue as a whole and variable between donors; the net result being a dilution of signals and increased noise due to inter-patient variability.
This leads to the unique capability of a small penetration depth and therefore high ablation rates, with high precision and a minimal heat-affected zone.
"The infected and the affected".
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com