CS is caused by mutations in the Harvey rat sarcoma viral oncogene homolog (HRAS) gene, with the majority of affected individuals carrying a mutation at the G12 position (Fig. 1).
In the Herceptin Adjuvant trial (HERA), with 3.6 years of median follow-up, all cases of severe CHF occurred during trastuzumab treatment; however, the cardiac condition of the majority of affected patients improved when trastuzumab was withdrawn [ 15].
In the Herceptin Adjuvant trial (HERA), with 3.6 years of median followup, all cases of severe CHF occurred during trastuzumab treatment; however, the cardiac performance of the majority of affected patients improved when trastuzumab was withdrawn [ 32].
A long recognised risk factor for breast cancer is a family history of the disease, although the majority of affected women do not have an affected close relative, and only 5 10% do have a true hereditary predisposition (Carter, 2001).
However, for many recessive diseases in outbred populations, the majority of affected patients are compound heterozygotes and the number of affected individuals in each family is small (1– 3).
Although the following pathways/complexes are not significantly affected by gene expression variances in total, embedded sub-pathways include the majority of affected genes, thus reaching statistical significance.
There are between six and 10 recalls of large appliances a year, according to Amdea, but, "unlike cars, if manufacturers need to make a safety adjustment they have no way of tracing the majority of affected models", its chief executive, Douglas Herbison, said.
The majority of affected people live in Africa and Asia.
The majority of affected users are Swedish, Norwegian and American, says the statement.
The majority of affected patients are females (90%%), aged between 40 and 60 years.
The majority of affected employees will be informed within 60 days with all the job reductions completed by mid-2017, according to the company.
