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"the major challenge" is a correct and usable phrase in written English.
It is typically used to describe a big or significant obstacle or difficulty that someone or something is facing. Example: The major challenge for the new company was breaking into a crowded market and establishing its brand identity.
Exact(60)
However, the vast majority of non-functional somatic variations remain the major challenge [ 9].
The major challenge lies in deciding which are causal.
However, blood loss remains the major challenge in liver surgery.
The major challenge concerned the quality of the DTM.
"The major challenge now is to ensure that people follow the jobs now being created".
And herein lies the rub and the major challenge for building a sustainable business.
She says lack of education is the major challenge in her family.
"Transport is the major challenge, of course.
The major challenge is to evaluate the fixed-point accuracy.
With variation the major challenge is student understanding of statistics.
However, the major challenge was found with the mixed patterns.
More suggestions(15)
the primary challenge
the broad challenge
the momentous challenge
the main challenge
the substantial challenge
the great challenge
the severe challenge
the enormous challenge
the fundamental challenge
the predominant challenge
the major challenges
the biggest challenge
the major challenging
the greatest challenge
the principal challenge
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com