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The phrase "the main factor" is grammatically correct and is commonly used in written English.
It can be used to refer to the most important or influential aspect of something. Example: "The main factor in the company's success was their innovative marketing strategy."
Dictionary
the main factor
adjective
Great in size or degree; vast; strong; powerful; important.
Exact(59)
"The main factor is this uncertainty.
But winnability is the main factor.
He pointed to the players as the main factor.
Marquee value was the main factor, she said, not controversy.
"The main factor is just being pain free.
But it's not the main factor causing the market turmoil.
But he insisted money would not be the main factor.
The main factor, the study says, is price.
But probably the main factor is Russia's economic boom.
The main factor is whether Judge Lake accepts probation officials' analysis of investors' losses.
Take finances, which is the main factor militating against family growth.
More suggestions(17)
the substantial factor
the foremost factor
the major factor
the overriding factor
the prominent factor
the predominant factor
the basic factor
the salient factor
the principal factor
the main thread
the dominating factor
the core factor
the main sail
the main difference
the main objective
the common factor
the main message
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com