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The phrase "the main case for" is correct and usable in written English.
It can be used when presenting the primary argument or rationale supporting a particular position or viewpoint. Example: "The main case for renewable energy is its potential to reduce greenhouse gas emissions and combat climate change."
Exact(2)
That's the main case for me.
Indeed, the main case for Scandinavian membership is to back up the Baltics.
Similar(57)
The European sector of the Arctic and subarctic regions including the high-Arctic archipelago of Spitsbergen provides the main cases for this study.
For the main case scenario, participants were asked to choose no more than 40 questions and 20 assessments.
A blood sample or a saliva sample was requested from all the subjects in the main case-control study for genetic analyses.
The main cause for these cases included drug related offences, stealing or damaging assets or properties, and physical assaults or murder.
The main case-control study instruments were questionnaires for cases and controls.
We had no pediatric cases, as the main cause for LSCD in children, chemical injuries, is exceedingly rare in our geographic area.
We consider two main cases for the value of M: the constant value case and the adaptive estimation case.
While iBooks looked to solve this problem, really the main use case for its Author tool is for teachers who want to publish books for their classrooms — those who aren't looking to even sell it in the first place.
"The main use case for Vize is data analytics and data discovery," co-founder and COO Noureddine Lakehal told me.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com