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Surprisingly, the lower efficacy agonist APO was the more efficacious positive reinforcer.
Biological factors could also help explain the lower efficacy in the younger women.
The question may be asked how the lower efficacy of Ringers acetate as a plasma volume expander in sepsis than in hemorrhage may be explained?
The authors demonstrated the lower efficacy of [11C]choline PET compared to that of [18F]FDG PET for tumour detection and therapy response assessment in vivo after surgical castration.
Even at the lower efficacy assumption, SPG stimulation was found cost-effective, with an ICER of €18,846 per QALY gained well below commonly acknowledged willingness-to-pay thresholds.
The panel agreed that the sterilization procedure used in Gorschewsky et al.'s study is to be considered responsible for the lower efficacy of the allograft, but that it is not currently adopted.
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Again, the AR initiation efficacy of poly(Fuc 100 is lower than for poly(Man 100 and poly(GlcNAc 100, consistent with the lowered efficacy of poly(Fuc 10.
Several mechanisms could contribute to the lowered efficacy of macroscopic activation, including a decreased affinity for cGMP, alterations in coupling of cGMP binding to channel opening, decreased open probability or single channel conductance, the loss of modulating protein/signaling interactions, and others; these are interesting questions to pursue in future studies.
One of the reasons for this lower efficacy of the HSA-stabilized nanoparticles could be an insufficient attachment of poloxamer 188 to the particles' surface occupied by HSA.
The TEF model fails at high doses because it cannot take into account the reduced effect that occurs when the lower-efficacy galangin competes with TCDD for receptors.
However, the number of patients receiving IPE 4 g/day in the lower-efficacy statin treatment group was smaller (n = 16) than those in the medium- (n = 132) and higher- (n = 69) efficacy statin treatment groups.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com