The combination AQ+SP was highly efficacious, despite the low efficacy of SP alone; however, we found evidence that AQ may exert selective pressure for resistance associated mutations many weeks after treatment.
The combination AQ+SP was highly efficacious, despite the low efficacy of SP alone; however, we found evidence that in these circumstances AQ may exert selective pressure for resistance mutations many weeks after treatment.
Tuberculosis remains a major infectious disease worldwide due to the low efficacy of available vaccine of the Mycobacterium bovis Bacillus Calmette Guérin (BCG).
The combined use of the quarantine/isolation strategy with a vaccination strategy will eliminate the disease, even for the low efficacy level of the universal strategy considered in this study.
Only 59.4 ± 15.9%6969 of 118, mean ± S.D). of NE treated BA show thermogenic responses, which accounts for the low efficacy of 0.1 μmol/L NE-induced thermogenesis in BA (Fig. 3E, F).
With this mito-thermometry, we revealed the low efficacy of NE-induced thermogenesis and the maximum transient rate of temperature increase in BA, and indicated the improper critique of Baffou both practically and theoretically.
Both antibodies were internalised by this MUC1 tumour cell line which can explain the low efficacy observed in vitro and in vivo.
The low efficacy found in this study contrasts with findings from some other studies which show that vaccine therapy in combination with antiviral drugs decreases HBV viral replication and HBV DNA to undetectable levels by inducing HBsAg-specific T-cells.
Although it is not clear how much B. parapertussis contributes to the resurgence of whooping cough, the low efficacy of current vaccines against this bacterium might confer a selective advantage to B. parapertussis, relative to B. pertussis.
Together, these data show that, in addition to rapid catabolism of peptide-HLA complexes shown in Figure 2, the low efficacy of cross-linking by the photo-activatable peptides may hinder the production of adequate numbers of "infinite" affinity peptide-HLA complexes to generate potent cytotoxic responses.
It is also unlikely that the low efficacy is due to drug resistance because of prior treatment.
