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However, the low conservation of these loci across the group suggests that they may have species-specific functions (Zheng et al. 2015;, Komiya et al. 2014).
This species difference may have its molecular basis in the low conservation of human and murine CD137 ligand.
To conclude, the low conservation of dispersal traits we detected here within species will undoubtedly impact both the evolution and the metapopulation dynamics of butterflies, and hence must be accounted for in metapopulation modelling.
However, this alone cannot account for the low conservation level we observed, as the numbers of sequences with low affinities in Pse (692 - 310 = 382 for Bcd and 2001 - 685 = 1316 for Kr, Table 2) are too large to be explained by misclassification of high affinity sequences (p<10−15 for both factors assuming the misclassification rates at 0.13 for Bcd and 0.22 for Kr, Binomial test).
We were surprised, however, by the low conservation of Apis vestigial (vg).
The low conservation of PNMA5 sequence led us to determine the sequences of PNMA family genes in the African green monkey.
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Results demonstrated that the current Welsh MPA network, even at the lowest conservation targets (≤10%), fails to suitably represent more than two-thirds of the broad-scale habitats found in its coastal waters.
The Top percent of conserved regions parameter is responsible for the elimination of the TFBSs with the lowest conservation scores.
Genes involved in immunity are known to evolve rapidly, presumably in response to selective pressures imposed by parasites and this could explain both the highest genetic variability and the lowest conservation of these genes in An. funestus compared to the other two categories analysed.
RNMs had the lowest Conservation Index, thus suggesting stronger negative selection acting against RNMs in particular.
This is the lowest conservation rate of any Notch pathway component we have looked for.
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