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Robustness is needed to account for architecture and algebraic singularities that are likely to occur, for example, when conducting an iterative optimization of the linkage at hand.
Dropping any one of these reading-related measures from the multi-variate model significantly reduced the linkage at DYX6, thereby implying that all measures were influenced by the underlying QTL.
Since the linkage at the remaining loci could not be explained by association of common variants, human familial longevity at these loci may be explained by rare variants.
PDCD1 (programmed cell death 1) is generally accepted as the gene responsible for the linkage at 2q34 [ 13], and it is also associated with lupus nephritis [ 14].
Combined modeling in the GEHA study showed that APOE4 (p = 0.02) and APOE2 (p = 1.0 × 10−5) account for the linkage at 19q.
If this MTP genotype is observed at high frequency in centenarians, but only in the presence of specific protective variants, this may in part explain why the linkage at chromosome 4 was not observed consistently between studies.
Similar(49)
As a consequence, all the linkages at the heart of England's much-improved attacking game – the Ben Youngs-Toby Flood axis at half-back, the Flood-Cueto connection in midfield, the Ben Foden-Chris Ashton double act out wide – were broken.
Though the pathways may appear obvious, evidence of the linkages at all levels is required to substantiate the framework [ 1].
A significant issue regarding the conformation of the FKBP52 FK1 domain in solution is the configuration of the Pro linkage at the tip of the β4 β5 loop.
A significant effect of the orientation and extension of hydrophobic regions around the ether linkage at the 3-position was found on the efficiency of DNA delivery.
The anonymous linkage at the individual level minimises the nominator-denominator bias.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com