Exact(3)
Based on this results, a dose of 5,000 mg/kg was selected as the limited dose, as recommended by OECD test guidelines.
According to the OCED protocol [ 35] S. rhombifolia extract can be classified as non toxic since the limited dose of an acute toxicity is generally considered to be 5.0 g/kg bw [ 17].
Specifically, the limited dose of BoNT/A in relation to the individual strength of the corrugator muscle may have been the reason that some patients ended up with only about 50% blockage of horizontal contraction 7 days after injection, while others reached 100% blockage of their horizontal fronto-glabellar contraction capability.
Similar(56)
The current shortfall has generated criticism over how the limited doses have been distributed, especially after reports that some corporations that offer flu shots to their employees, who are mostly young and healthy, received their allotments before doctors, hospitals and health departments.
This study indicates that stevioside and steviol are neither mutagenic nor clastogenic in vitro at the limited doses; however, in vivo genotoxic tests and long-term effects of stevioside and steviol are yet to be investigated.
Based on these results, a dose of 2000 mg/kg/day was selected as the toxicological limited dose recommended by the Organization for Economic Cooperation and Development OECDD) guideline (1997: Principles of Good Laboratory Practice).
Based on these results, a dose of 2000 mg/kg/day was selected as the toxicological limited dose recommended by the OECD guidelines.
SIB is explored earlier for other cancers [ 5– 9], showing a good coverage of the boost region, with limited dose spread to the surrounding tissues and without excess of dose to the organs at risk (OAR).
Treatment techniques with beam arrangement based on the tangent angles can have a limited dose to the ipsilateral lung and the contralateral breast but are difficult to generate a concave dose distribution conforming to the breast target.
Other significant limitations to this study include, but are not limited to, the brevity of the trial, high placebo response rate, limited dose range of fluoxetine, and the inclusion of youth who met criteria for depressive disorders other than MDD.
However, this is not surprising given the relatively low doses and limited dose range in the TRC.
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