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There exist certain limitations associated with present study, and some of the limitations point to promising direction for further research.
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In spite of the limitations pointed above, spotted cDNA microarray analysis is a powerful tool to identify candidate genes in comparative gene expression studies in cancer.
In summary, the limitations pointed out by Goodman et al. would serve to underestimate our estimate of effect, not inflate it.
Despite the limitations pointed out about the evolution of the questionnaire between 1993 and 2012, it is a real asset to have Swiss data from these two European studies carried out twenty years apart.
Spanswick agrees to some degree with the limitations pointed out by Krebs, but adds, "We hope the process will eventually be used to prepare large-volume plastic materials where purification costs are important".
All these limitations point out the direction for future studies.
All these limitations point to the need for implementing a well design job rotation program along with a well-designed intervention study in order to fully and robustly evaluate the theory of job rotation and its application.
Furthermore, these methodological limitations point to the need to confirm the results quantitatively.
The second limitation point is the α-KGDHC reaction.
To avoid the limitations of point estimation, interval estimation is applied to describe the stochastic behavior according to the normal distribution, which is used to approximate the binomial distribution.
The limitations also point to opportunities for future research.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com