This is important because true protein complexes must admit a topology of pairwise binding at the level of interfaces, and these interfaces are often exclusive (Aloy and Russell, 2006; Kim et al., 2006).
Similar to the latter, we obtained low πmax values for the three BH3 peptides assayed (Figure 5), indicating a weak insertion in the monolayers, most likely at the level of the interface of the phospholipids.
Similarly to the D-DALK group, the presence of multiple bright microdots at the level of the interface was a frequent finding although not observed in all eyes.
Traumatic disruption of the vessels or formation of vascular thrombosis may lead to ischemia-induced lysis of bone at the axial aspect of the PSBs at the level of the interface with the ISL [ 1, 2].
Work with human and mouse Sef has similarly shown differences with Sef, either acting at the level of Ras interface or downstream at the level of MEK (Kovalenko et al, 2003; Xiong et al, 2003; Yang et al, 2003; Ren et al, 2006; Ziv et al, 2006).
The Health Centre II represents the first level of interface between the formal health sector and communities and typically provides only ambulatory services at the parish level (with a standard population of 5,000 individuals).
Firstly, the degree of filament bending due to the curvature of the cell membrane in vivo is tiny at the level of subunit interfaces and much smaller than the bent filaments that have been observed by EM.
However, it is important that the actual raw information that was used to determine each drug's individual rank becomes available, so that the ranking scheme could be further and more easily enhanced by considering drug drug interactions at the level of blood CNS interfaces and possibly other factors (e.g. toxicity issues) as they come to light.
The first level of interface with the Cloud service (the abstraction layer) is done to the level of the language-dependent APIs through the so-called Cloudlets and Connectors.
Accurate control of the RIE process was the key in achieving the high level of interface flatness.
