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Homogenization among ZF domains in human and mouse is even more striking at the level of DNA sequence (Figure 4).
However, the fundamental unit of heritable variation in transcript abundance is the underlying regulatory allele, and as a result it is necessary to understand gene expression evolution at the level of DNA sequence variation.
Importantly, however, the products were not analyzed at the level of DNA sequence.
Candidate genes were selected according to the level of DNA sequence similarity to genes previously identified as reference genes in Arabidopsis and cotton.
However, because of the extensive genetic mapping done with N. crassa, most classical markers are flanked by genes that have been identified to the level of DNA sequence.
Our data reveal that CTCF binding sites have evolved under two regimes, whereby some CTCF elements are constrained both at the level of DNA sequence as well as in their binding while other CTCF elements exhibit significantly more flexibility.
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In the 1960s, when existing techniques were extended to the level of DNA sequences and amino acid sequences of proteins and combined with a burgeoning knowledge of cellular processes and protein structures, a whole new set of computational methods was developed in support of molecular phylogenetics.
In the 1960s, when existing techniques were extended to the level of DNA sequences and amino acid sequences of proteins and combined with a burgeoning knowledge of cellular processes and protein structures, whole new computational methods were developed in support of molecular phylogenetics.
Ideally, one might want to introduce the random changes at the level of DNA sequences and use a reliable molecular ab initio prediction system to determine the resulting changes in kinetics that are then used as input for the corresponding systems biology models.
Graustein et al. [ 17] compared the levels of DNA sequence polymorphism among three closely related species in the genus Caenorhabditis: two self-fertilizing species, C. elegans and C. briggsae, and one cross-fertilizing species, C. remanei.
The exact level of DNA sequence restructuring events involved in this important evolutionary process remains to be determined.
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