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The phrase "the least possible interference" is correct and usable in written English.
It can be used in contexts where minimizing disruption or disturbance is important, such as in discussions about communication, technology, or processes. Example: "We aim to conduct our research with the least possible interference to the local wildlife."
Exact(3)
We want the least possible interference in the interests of a quick return to reasonable calm in Egypt".
One minute he was a 12-year-old ragamuffin with nothing in his head more compelling than the desire to get through the day with the least possible interference from his elders, and the next he was in possession of one of life's most enduring certainties.
Discontinuation of monitoring immediately before withdrawal of life-sustaining treatment is common practice in our unit in order to give parents time with their child with the least possible interference from medical technology.
Similar(54)
The least possible.
He promises "the least possible impact".
More recently, minimum interference routing algorithm (MIRA) that aims to select path as to ensure that the chosen path blocks future requests to the least possible extent is proposed [12].
The disadvantages are the possible interference between multiple recombinases, DNA loss by excision, and reversibility of the reaction.
Dr. Norman Krinsky of Tufts University, who headed an Institute of Medicine panel on antioxidants, said the study "raises a real question" about the possible interference of the nutrients with cholesterol drugs.
The possible interference of the mixing cations was also investigated.
The only possible interference that we can think of would be (M2O 2+.
Concerns were also raised on the possible interference of ibuprofen on the albumin-bilirubin binding [ 51].
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com