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The phrase "the leading reason" is correct and usable in written English.
You can use it when you want to refer to the primary or most important reason for something. For example, "The leading reason for the rise in unemployment is the lack of job opportunities in the area."
Exact(60)
Among the foodborne microorganisms, bacteria are the leading reason for serious outbreaks and lead to spread the diseases irrespective of the region.
And the leading reason people seek out counseling is loneliness.
Not surprisingly, it is the leading reason for liver transplants in the United States.
Across all incomes, arguing about money was the leading reason for divorce.
Excess weight is the leading reason the Army rejects potential recruits.
Hepatitis C, caused by a virus, is the leading reason for liver transplants in the United States.
It's the leading reason for liver transplants, which are among the most expensive of all medical procedures.
Hepatitis C, caused by a blood-borne virus, is the leading reason for liver transplants in the United States.
But conflicts over jobs are the leading reason reservists quit, according to Pentagon surveys, followed by separation from their families.
The leading reason for false-positive results (n = 480) was having other eye conditions (n = 458 [95.4%]), mainly including physiologic cupping (n = 267 [55.6%]).
The leading reason, according to Chayes, "was not ethnic bias, or disrespect of Islam, or concern that U.S. forces might stay in their country".
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com