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(If Aquinas had given us a satisfactory account of this, he would have thereby solved the leading problems of epistemology).
Shear stress-induced apoptosis is one of the leading problems in seeding cells of tissue-engineered blood vessels (TEBVs).
Then, when a thermostat is designed or validated, one of the leading problems that must be tackled is the usability evaluation.
Since the invention of computers, the calculation of arithmetic and logic operations using digital circuits has been one of the leading problems in processor designs.
Lack of collaboration between individual systems and System of Systems (SoS) program management is identified as one of the leading problems in SoS engineering.
Magnetic exchange interaction, one of the leading problems in the field, is tackled in some detail from two viewpoints: heuristic models based on Hund Mulliken and Heitler London schemes and computational methods.
One of the leading problems that app publishers want to solve is how to make money from their apps.
The systolic arterial hypertension and the exercise-induced hypertension are the leading problems.
Ovarian cancer is one of the leading problems in gynecologic malignancy in females worldwide.
Antimicrobial resistance (AMR) in bacterial pathogens represents one of the leading problems facing modern healthcare services globally.
Throughout the 1940s and 1950s, a small but influential group of British psychiatrists echoed Rothschild's claim that 'psychoses of the aged now appear as the leading problems of psychiatry' (1941: 324).
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com