We suggest that both the potential for discrete phenotypic variation despite random mating and the larger effectiveness of assortative mating may increase the likelihood of evolving assortative mating and sympatric speciation.
Although this study is not representative of the set of studies included in the meta-analysis, the extremely large effectiveness found in it advises that new studies try to replicate their results by implementing interventions similar to that applied in this study.
More than 47,300 children were enrolled, making this the largest IPD effectiveness trial of PCVs in children.
The authors of the review noticed that in the Sequenced Treatment Alternatives to Relieve Depression (STAR*D) study, the largest antidepressant effectiveness trial ever conducted, there was an apparent progressively increasing dropout rate across each study phase [ 7].
There is limited evidence on the large-scale effectiveness of KMC under real-life implementation conditions, but the two observational studies reviewed above suggest a beneficial impact on neonatal mortality.
It is the largest known comparative effectiveness study of rituximab versus anti-TNF therapy in the USA and included a nationwide sampling of patients with RA.
Program and study retention may be lower than most small-sample-size studies of Web-based programs for psychological disorders, which range from 17to9898 % with an average of about 70%% [ 34]; the rates are comparable to larger effectiveness studies [ 19, 35] and may be more reflective of real-world settings.
Shear strength and thickness of the adhesive bond were the largest factors in the effectiveness of patch repair.
The results show that the higher is the concrete strength class the larger is the effectiveness of the NSM technique.
The trial is the largest RCT examining the effectiveness of corticosteroid for heel pain to date.
Although the target of enrolling 768 subjects was not reached, the fact that 600 treatment-naive subjects were enrolled makes this, to our knowledge, the largest study of the effectiveness and safety of first-line latanoprost conducted to date.
