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The phrase "the largest difficulty" is correct and usable in written English.
It can be used when discussing the most significant challenge or obstacle in a particular context or situation. Example: "The largest difficulty we faced during the project was coordinating the schedules of all team members."
Exact(3)
The largest difficulty in considering the Kerik downfall is knowing in which niche of public disgrace to categorize him.
The fact that Mac users will be asked to move into the future by stepping into the past underscores the largest difficulty for Mr. Jobs since he returned to run Apple in 1997.
If adults can simultaneously hold two search templates in working memory, and run behavior can be used to estimate that ability, we expected 4-year-olds to have the largest difficulty with simultaneously holding two target categories in mind.
Similar(55)
One of the largest difficulties in fatigue damage is to find a representative 'Damage indicator' which can be easily connected with the Wöhler curve taken as known data of the material.
Music supervisor Ivan Pavlovich has cited the large scale of the game as one of the largest difficulties when producing the score.
One of the largest difficulties facing epidemiological research is that of measurement error in an exposure or relevant confounders [ 1- 4].
But the larger difficulty facing Pat Mulroy and Peter Binney, as they describe it, is re-engineering the culture and conventions of the West before it becomes too late.
This effect represents the larger difficulty that individuals subject to higher technical innovation in the workplace face in order to remain in the labor market.
The anatomical features of the male urethra are different from females in terms of length, stegnosis and arcuations; these differences may predispose male infants to urinary tract calculi because of the larger difficulty in passing stones.
Zeroing in on the strategic decisions of both major parties, the directors, James D. Stern and Adam Del Deo, illuminate not only the putative blunders of the Kerry-Edwards campaign but also the larger difficulties of the Democratic Party itself.
Above all, experts say, the difficulties in streamlining ERT are emblematic of the larger difficulties of changing anything in the Greek public sector, a vast web of overlapping and interconnected interest groups, each one dependent on the other for survival.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com