The hope at the time was that the larger studies would refute the findings of the smaller one.
The larger studies, which used more than 1,000 participants, consistently found little difference between formula-fed and breast-fed babies, the authors of the BMJ report said.
In the larger studies, almost every cause of death was higher among bipolar patients: cardiovascular, respiratory, cerebrovascular (including strokes), and endocrine (like diabetes).
But the agency has never faced a situation like this, in which the larger studies, known as the intact trials, already showed that Iressa did not prolong lives when used as initial therapy.
And they criticize the larger studies of Prozac and suicide, citing problems in methodology, and pointing out that they were carried out by scientists financed by Lilly or working for the company.
The larger studies are >15 years old.
However, the larger studies on Nocardia sp. keratitis have been conducted in less urbanised areas, leaving the potential for population bias [2, 16].
Smaller studies (n < 100) generally reported favorable results of anticytokine therapy on cardiac function, but only one of the larger studies (n > 100) evaluating IL-1β inhibition presented positive results on outcome.
They did press on with their empirical and theoretical efforts during the time of upheaval in the 1930s, producing various small studies in the Zeitschrift für Sozialforschung, and the larger Studies on Authority and the Family.
Furthermore, the larger studies tended to have more neutral results, leading to additional concerns about the usefulness of some past research (Nasar et al. 1983; Kaplan and Herbert 1988; Nasar 1988; Loewen et al. 1993).
Furthermore, when setting weights to the different studies in the fixed-effect model, we can largely ignore the information in the smaller studies since we have better information about the same effect size in the larger studies.
