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The key difficulty is how to model and handle the inter-cell interference.
The key difficulty is how to explain in naturalistic terms the generation of consciousness by "mere matter".
The key difficulty is that operating in everyday listening conditions entails processing a speech signal that is reverberantly mixed into a noise background composed of multiple competing sound sources.
The key difficulty is that cancer is a complex and heterogeneous disease: many genes are amplified, deleted, mutated, and up- or down-regulated.
Similar(56)
The key difficulty was that validation was only possible in a relatively small subset of the population who actually reported an event.
One of the key difficulties is a lack of sensitive assays to detect de novo deletions, which in normal tissue may be lower than 1 deletion per million genomes, and track the kinetics of their initial selection.
One key difficulty is the availability of broadcasting spectrum to make local or city TV a reality, since mobile operators are expected to take precedence in an auction of transmission frequencies freed up by digital switchover.
A key difficulty is the migration of Irish trained doctors once they have qualified or completed their pre-registration (intern) year.
A key difficulty is that Mei Xiang places herself in what he called "pancake position" — flat on her stomach, legs outstretched — and Tian Tian isn't assertive enough to lift her off the ground.
A key difficulty is that stakeholders typically convey their goals indirectly through intuitive narrative-style scenarios of desirable and undesirable system behaviour, whereas goal refinement methods usually require goals to be expressed declaratively using, for instance, a temporal logic.
A key difficulty is that this plot is so predetermined there is little point in seeing it through to the end.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com