The NF-κB and Akt regulators, the key controllers of the pathways showing early activation/late repression expression mode (i.e. inflammation, immune response, cell proliferation and cell differentiation), have been previously reported to act synergistically [56] [59].
This synchronous swap of the major functional signatures between the early and the late phase and the fact that the key controllers of the reciprocally regulated processes (as revealed by the network analysis (Figure 4, Figure 5)) are implicated in the mutual repression suggest that the regulatory exchange may occur via tightly controlled reactions, limited to few master regulators.
Transcriptional network analysis identifies NF-κB, NEMO, Akt, PPARγ and SREBP1 as the key controllers of these processes and suggests that direct regulatory interactions between these factors may govern the transition from early (stressed, inflammatory) to late (pathological, steatotic) hepatic adaptation to HF feeding.
Polycomb groups are correlated with transcriptional repression of Nanog, Oct4, and Sox2 which are the key controllers of Human ES cell pluripotency.
Become the key controller.
Finally, intracellular Zn2+ can interfere with neuronal excitability by modulating the activity of the neuronal K+ transporter, KCCN, a key controller of the neuronal resting membrane voltage potential.
The transcription factor nuclear factor-kappa B (NF- κB), a key controller of the inflammatory process, is activated by a large number of stimuli including microbial pathogens, tissue injury and necrosis among several others (Karin, 2006).
In conclusion, we have discovered that periodontal disease is associated with significant decreases in the circulating concentrations of one endoplasmic reticulum molecular chaperone, BiP which is a key controller of the unfolded protein response [36] and a mitochondrial molecular chaperone involved in protein folding within this organelle.
Here, by using two neuronal cell lines (GT1 7 and GN11 cells), derived from gonadotropin hormone releasing hormone (GnRH) neurons, we describe the mechanisms involved in the perturbation of calcium signaling, a key controller of neuronal function.
The TOR pathway is a key controller of cellular metabolism, by coordinating nutrient supply and available energy with cellular demands for protein synthesis and growth.
