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A number of reports have raised the issue of specificity and efficiency of gene transfer [ 3, 4], specifically to neoplastic cells.
However, more recently, the issue of specificity has been questioned as several groups have demonstrated that various mismatches between the guide strand of the siRNA and the mRNA target do not abolish the silencing effect of the siRNA [37], [38].
For genome-editing techniques, the issue of specificity and delivery is paramount.
Further complicating the issue of specificity of indicators is the difficulty adolescents have in reporting their parents' education and occupation.
During evolution, as new signaling pathways emerged from the duplication and divergence of pre-exiting parts, the issue of specificity must have been paramount.
As mentioned above, overcoming the issue of specificity as well as discovering highly sensitive markers for early detection are undoubtedly important.
Similar(50)
The development of tumour-specific contrast agents may provide a simple answer to the issues of specificity.
More broadly this paper highlights the issue of epitope specificity of monoclonal antibodies directed against disease-associated markers, specifically when they are glycoproteins.
This paper highlights the issue of epitope specificity of monoclonal antibodies directed against disease-associated markers, specifically when they are glycoproteins, as is the case for many cancer markers.
New assays for genome-wide identification of off-targets have provided important insights into the issue of cleavage specificity in vivo.
For this reason, I thought that I should emphasize the issue of domain specificity in subsequent lessons.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com