The current cross-sectional study does not address the issue of cause and effect relationship between vitamin D3 and SLE.
One approach to resolving the issue of cause or effect would be to date the duplications by comparing the relative ages of tandem gene pairs in Daphnia associated with meiosis to the ages of tandem duplicate genes not associated with meiosis.
The issues of cause versus effect require further investigation particularly in the role of ageing.
In 1998, Larry Page and Sergey Brin made a promise: "We believe the issue of advertising causes enough mixed incentives that it is crucial to have a competitive search engine that is transparent and in the academic realm".
"The issue of sleep causes a lot of guilt by women," Dr. Love said.
On the issue of what caused the Soviet Union to collapse, that is another set of issues, and a lot of it had nothing to do with Reagan.
People's posts suggested that the issue of diagnosis causes confusion.
In the other scenes, the issue of what is causing Conrad's pain is either avoided or belittled.
She also charged that the American news media had "hyped" the issue of food safety, "causing serious damage to China's national image".
We also ruled out the issue of secondary structure causing the 3' end of our Test Template to become inaccessible.
