Exact(2)
DOI: http://dx.doi.org/10.7554/eLife.06132.002 The invariable development of drug resistance presents a critical challenge to the success of targeted cancer therapies (Jänne et al., 2005; O'Hare et al., 2006; Poulikakos and Rosen, 2011).
However, the invariable development of drug resistance greatly limits the effectiveness of this therapy, despite efforts to circumvent acquired genetic abnormalities, such as the recurrent T790M-EGFR gatekeeper mutation or MET amplification.
Similar(58)
Furthermore, this study shows the invariable occurrence of DD/ID and the occasional (8.8%) development of hepatoblastoma, thereby showing the necessity of adequate support for DD/ID and screening of hepatoblastoma in affected patients.
As Henry Stanley put it, tsetse were the invariable sign of "an extensive habitat of game".
The invariable specialty of the house, however, is a gorgeous crèpe Suzette.
He didn't just "experiment" with marijuana, the invariable confession of boomer politicians.
The limitations are the invariable result of the consistent failure of federal, state and local governments to work for racial integration throughout the region.
"It is the invariable stand of the D.P.R.K. government to find a peaceful solution to the nuclear issue on the Korean Peninsula," the Foreign Ministry statement read.
Probably the closest current representation of the disk is known as the invariable plane of the Solar System.
By bringing our awareness to the invariable presence of our self-talk, we can tune in and become receptive to the messages that we are communicating to ourselves.
The fact that mutations in CSN5 and Nedd8, the invariable components of the CSN machinery, result in identical defects indicates that CSN is involved in common mechanisms of control of neuronal development.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com