The development starts from the local electromechanical equivalent inclusion principle through the introduction of the position-dependent equivalent eigenstrain and electric field.
SIDS rates decreased markedly around the world with the introduction of the back sleeping position; in New Zealand, SIDS rates fell from 4.4 per 1000 live births in 1988 [ 7] to 1.6 per 1000 live births in 2002 [ 3].
Interestingly, the introduction of the bulky bromine in position 7 enhanced selective DYRK inhibition only when combined with the carboxylate substitution, which was evident comparing 6d and 6i.
In general, the introduction of the substituent in ortho-position of the phenyl ring increased the basicity of the molecule.
In addition, we predict that the introduction of the bulky hydrophobic Trp at position 1699 will likely interfere with docking of the peptide +3 position into the BRCT peptide-binding groove.
The introduction of the phenyl hydrazide motif to the position 5 of the pyrido[2,3-d]pyrimidine scaffold led to the inhibitory effect in two signaling pathways: inhibition of AKT activation in the phosphatidyl inositol 3′-kinase (PI13K /AKT signaling pathway and the inhibition of ERK and JNK activation in MAPK pathway.
Moreover, the position of the introduction of the hydroxyl group is crucial to producing a long hydroxy fatty acid, which, after β-oxidation, will produce the proper hydroxy acid molecule.
On the introduction of the defect, changes in atomic positions propagate to large distances with amplitudes dropping off slowly with distance.
This is, however, hypothesized not to pose a big threat to reliability as the assessment of CNCR interviews were in place years before the introduction of the FACT teams and were never positioned in an evaluation of FACT.
Additionally, methods for direct fluorination and trifluoromethylation do not always allow the introduction of the CF3-group at the required position of a molecule.
