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To differentiate the anchoring from the internalization process, we carried out the ND-cell incubation at 4 °C.
Genedani, S. et al. Computer-assisted image analysis of caveolin-1 involvement in the internalization process of adenosine A2A-dopamine D2 receptor heterodimers.
A clear co-localization was observed between the viral glycoproteins and clathrin and dynein during the internalization process.
Mouse α-Syn amyloid fibrils are readily endocytosed in the murine neuroblastoma Neuro-2a (N2a) cells expressing functional PrPC compared to cells in which PrPC expression is absent, suggesting that PrPC could in part mediate the internalization process.
Genedani S, Guidolin D, Leo G, Filaferro M, Torvinen M, Woods AS, et al. Computer-assisted image analysis of caveolin-1 involvement in the internalization process of adenosine A2A-dopamine D2 receptor heterodimers.
The micelle surface hides TAT during circulation, which has the strong capability to translocate the micelle into cells, and exposes TAT at a slightly acidic tumor extracellular pH to facilitate the internalization process.
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Imaging of the internalization processes at high resolution may help to understand the molecular details of these processes in the future.
In addition, the antigen presentation processes, including the internalization, processing, and presentation of antigenic protein and competing protein, are also captured by the model (Supplementary Figure S1).
The knockout of oppD causes the inactivation of the entire transport system because this gene encodes the protein responsible for providing energy to the peptide internalization process through the hydrolysis of ATP [ 14].
Altering the CysLT1R internalization process at either the clathrin or the arrestin-3 stage led to disruption of LTD4-induced Erk1/2 activation and up-regulation of COX-2 mRNA levels.
It is worth emphasizing that the aim of our analytical framework is to develop a simple but scientifically rigorous model that may be used to predict the optimum antibody kinetic properties and concentration required to achieve a desired protective effect rather than develop a detailed, biologically accurate model that captures all the details of the toxin internalization process.
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