In addition, the mechanisms through which the EGFR-driven signaling network contributes to adaptation and treatment resistance deserve wider characterizations beyond the traditional "linear pathway" view of signaling, into one of integrative interaction networks.
User understanding of models and their behaviors is assisted via integrative interaction.
Could the molecular complementarity between SUMIs involved in acidocalcisome metabolism have resulted in the formation of self-organizing composomes in which integrative interactions between SUMIs (in the appropriate conditions) converted energy into biologically useful forms such as polymerization?
The text within this very sentence "…via integrative interactions between hyperstructures, convert this energy into biologically useful forms" is truly obscure and unless supported by more formal arguments needs to be eliminated.
The meeting forum seeks to achieve this goal through integrative interactions across multiple platforms of knowledge and people, as shown earlier in Figure 1, and will form the basis of discussions for iCOMOS-2016.
The final subset of statistically significant SNPs (n = 34) was selected and their genes assessed for biological interaction using the Integrative Multi-species Prediction (IMP) algorithm that integrates genomics data from thousands of sources [ 11].
In most cases, because the integrative force of the interactions between stress and vulnerability does not reach to the threshold for a pathogenesis of anxiety, the direction leads to the formation of fear memory, which is featured by many adaptive responses such as an acute HPA axis response and many others (Fig. 7B).
In the case of extensive stress or a higher vulnerability, the integrative force of the interactions reaches over the threshold, and thus the direction is leading to the pathogenesis of anxiety, which consequently produce maladaptive responses including a chronic HPA axis activity and many others.
Comparing the proposed paradigm with a drug-disease gold standard demonstrated the robustness of the integrative paradigm in predicting drug-disease interactions.
By employing the gene enrichment function in miRTar [ 28], the putative or experimentally verified miRNA-gene interactions identified through the integrative database searches were mapped to KEGG (Kyoto Encyclopedia of Genes and Genomes) [ 29] to reveal the biological importance of these molecular relationships.
