Sentence examples for the integrated role from inspiring English sources

The main objective was to establish the integrated role of spatial and seasonal changes in the sedimentary abiotic environment in relation to the establishment of the halophytes zonation pattern.

Multiple approaches such as cell activity assay, biochemical detectation, flow cytometry and fluorescent were used to study the integrated role of ROS homeostasis, mitochondrial redox metabolism and cell apoptosis as well as chemical stability of these drugs.

This finding highlights the integrated role of TMPRSS2-ERG gain and NKX3.1 losses as cooperating events in prostate tumorigenesis.

In the present study, we used a dietary model of obesity to address the integrated role of biomechanical and inflammatory factors in the pathogenesis of osteoarthritis, and we investigated the effect of dietary obesity on factors affecting pain-related behaviors in mice.

Given the integrated role of S1PR1 and pSTAT3 in oncogenesis [ 22] and the above observation that suggested a possible complementary effect of S1PR1 and pSTAT3 on the prognosis of DLBCLs, we made a new immunohistochemical variable combining S1PR1 and pSTAT3 expression, specifically, a S1PR1/pSTAT3 risk category.

The gene to gene interaction analysis shows allele F and predisposing MHC alleles to have significant interaction suggesting the integrated roles of the MHC alleles in antigen presentation and VDR-F allele in enhanced autoimmune responses since shorter F-VDR has been shown to result in higher NF-kappaB and NFAT-driven transcription as well as higher IL-12p40 promoter-driven transcription [40].

We now show the integrated roles of the antiapoptotic BCL-W and BCL2 in affecting responsiveness to the antiestrogen ICI 182,780 (ICI; Fulvestrant Faslodex), using both molecular (siRNA; shRNA) and pharmacologic (YC137) approaches in three breast cancer variants; MCF-7/LCC1 (ICI sensitive), MCF-7/LCC9 (ICI resistant), and LY2 (ICI resistant).

However, by examining several proposed mechanisms in an in vivo animal model during controlled physiological conditions we are able to study the integrated roles of the different mechanisms for oxygen sensing.

The second phase deals with an analysis of the possible integrated role of the DAs in the coming programming period.

The universal, comprehensive and integrated role of the Brazilian CHWs contrasts with the existing vertical, targeted and fragmented approaches currently deployed in North Wales, and the rest of the UK.

For these integrated roles of ER a special redox homeostasis and a high luminal Ca2+ environment are required [ 8, 9].