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As an alternative to the machine-compatible web API's, a GUI based dashboard webapp was created to facilitate human interaction with the integrated dataset.
Future work will involve using the integrated dataset to explore long-term effects of control strategies on global HPAI H5N1 outbreaks, identify long-term variations in disease patterns and dynamics, detect potential mechanisms of driving its spread, conduct multi-scale analysis on various risk factors, and evaluate potential impacts of climate change, among others.
PLS-discriminant analysis correlations of the integrated dataset.
Thus, the integrated dataset had 2,968 expression profiles with the same median value (i.e., 1.00).
The figure also shows the "integrated dataset" that can be constructed by de-pseudonymizing the dataset.
We conducted experiments on the integrated dataset of 2,692 samples (see Section 2.2).
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With the integrated datasets at hand, discrepancies in putative regulatory connections can be easily detected.
The approach is then applied to a series of published breast cancer studies and we show that the integrated datasets possess increased statistical power and improved prognostic ability, compared to the individual datasets alone.
In this work, we extended and modified the layered modeling framework to identify association modules of driver molecular aberrations and passenger gene/mircroRNA expressions from the integrated datasets of NCI-60 cell lines.
In order to extract the modules (see Table 1 for the complete summary), we applied two different network clustering algorithms, C finder and MCODE, to all the disaggregated and the integrated datasets, and then compared the retrieved modules.
Summary: OmicsAnalyzer is a Cytoscape plug-in for visual omics-based network analysis that (i) integrates hetero-omics data for one or more species; (ii) performs statistical tests on the integrated datasets; and (iii) visualizes results in a network context.
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