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As in non-diabetic lenses, the inner nuclei of cataractous lenses from diabetics were significantly more compacted than those of non-cataractous diabetics.
Employing transmission electron microscopy (TEM) in an additional study [ 9], extensive fiber cell damage was noted in the outer adult nucleus of late-onset diabetic cataractous lenses, with minimal morphological disturbances in the inner nuclei.
The anterior and posterior disks of tissue overlying the inner nuclei were removed with forceps, and the process repeated until the distinct Y-suture pattern could be resolved on the lens surface (indicative of the FN).
The inner nuclei zone of both cells exhibited a significantly higher stiffness than the outer cell membrane/cytoplasm, and cancerous cells CaSki possessed a lower whole-cell stiffness and a softer nuclei zone.
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IVDs have two distinct regions, the inner nucleus pulposus (NP) which is jelly-like and rich in glycosaminoglycans (GAGs) and the outer annulus fibrosus (AF) which is organized into highly collagenous lamellae.
Retinal swelling in our I/R model has been shown to be due to the increase in inner retinal thickness [23]; therefore, retinal swelling was assessed by measuring the inner retinal thickness from the inner limiting membrane (ILM) to the inner nucleus layer (INL).
It is known that Sec61β in the inner nucleus membrane (INM) is required for the release of epidermal growth factor from the INM to the nucleus [ 19].
The more acute angles in aged lenses as compared to adult lenses signify that compaction occurred along the polar axis in the inner nucleus.
Low back pain is a common clinical problem that is attributed to degeneration of the intervertebral disc (IVD), and specifically the inner nucleus pulposus.
The inner nucleus behaves like a compressible gel (Rowat et al., 2006) and the nucleoskeleton is 5- to 10-fold stiffer than cytoskeleton (Simon and Wilson, 2011).
Clinical issue Low back pain is a common musculoskeletal problem attributed to degeneration of the intervertebral disc (IVD) and, more specifically, the inner nucleus pulposus (NP).
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