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However, B cells expressing these receptors take time to disappear, suggesting that anergy is the initial tolerance mechanism (T. Kawahara et al., unpublished observations).
The initial tolerance curve predicted whether head injury would occur as a function of the head impact duration and the average linear acceleration measured at the occiput.
The obtained results show a standard deviation of the boundaries, over the thousand realizations, which is smaller than the initial tolerance on each parameter.
This explains the initial tolerance of the host immune system towards PCV2, as measured in the control and CysA pigs' recurrent low viremia with no PCV2-specific IgMs or IgGs (Table 1).
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One author, Rudolph Sabor, sees a link between the Oceanids' treatment of Prometheus and the Rhinemaidens' initial tolerance of Alberich.
We find that 98.5%, 96.9%, and 92.0% of branches were matched to within the original tolerance for (epsilon_{0}=0.1500, 0.0750,mbox{and } 0.0375) respectively - even though we allow this tolerance to fall off if a matching tree is not found after (N_{mathrm{t}}=50) trials it is clear that the majority of cases are actually matched at the required initial tolerance.
This represents an initial tolerance checkpoint, with the vast majority of the newly generated B cell repertoire not surviving to exit the BM, 32 with cell death occurring through apoptosis.
The initial mass tolerance was set to 7 p.p.m. and MS/MS mass tolerance was 0.5 Da.
Important questions remain at this stage as to whether P140 peptide induces initial tolerance by playing the role of antagonist or partial agonist of the receptor of autoreactive T cells, or by using another mechanism, as previously discussed [ 9].
The initial mass tolerance in MS mode was set to 7 p.p.m. and MS/MS mass tolerance was 0.5 Da.
Non-fasted plasma glucose concentrations at the onset of the initial glucose tolerance test (GTT), 4 h after the morning meal, were all within the normal fasting range for well-fed sheep of moderate body condition (3.25 to 4.50 mmol/L (ref. 37)).
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