Since the initial implication of UNG2 in CENP-A assembly, many other proteins have been proposed as CENP-A assembly factors in metazoans (reviewed in [6]).
Based on this result and the initial implication of the gene in mineral metabolism, it was suggested that STC1 may have acquired an important function in reproduction during its evolution in mammals [ 70].
Thus, both the initial context and the ultimate implications of the solution to this problem are biological in nature.
Our results have also important mechanistic implications for the initial steps of the pathogenic conversion process.
We apologize for the confusion due to the minimal description of our synchronization method and its implications in the initial version of the manuscript.
However, the demonstration that ASA induces a short-term negative effect, by the increase of oxidative stress and related endothelial dysfunction, could have relevant pathophysiological implications in the initial phases of vascular injury, such as in the restenosis after percutaneous coronary intervention.
Because hybridization of A. thaliana accessions occurs regularly in the wild (A bbott and G omes 1989; B ergelson et al. 1998; Nordborg et al. 2005; P icó et al. 2008), our results have important implications for the initial stages of adaptation via flowering time.
We demonstrate the policy implications of initial TB and HIV prevalence, of HIV mortality, of degree of treatment aggressiveness, and of the target time at which outcomes are evaluated.
But a common finding in habituation experiments is that responding initially increases before declining; the implication is that the initial presentations of a stimulus result in more sensitization than habituation, while further presentations produce more habituation than sensitization.
Such resources can be re-visited as frequently as parents require so that they are better able to absorb the information and can begin to build a deeper understanding of the medical terminology, and the medical facts and their implications, especially in the initial stages of their exposure to intensive care and end-of-life decisions.
